Abstract Library
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#2841 Novelties in Primary and Metastatic GEP-NENs Clinical Outcome Investigation
Introduction: Gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs) WHO classification, using strict cut-offs, should reflect their biological features. In real world, strict cut-offs not adequately segregate prognostic groups, in particular on metastasis (M).
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Milione M
Authors: Kankava K, Maisonneuve P, Mangogna A, Centonze G, Cattaneo L,
Keywords: Gastro-entero-pancreatic neuroendocrine neoplasms, primary tumor, metastasis, Ki-67, mitoses, tumor deposits, clinical outcomes,
Introduction: Stromal Immune Contexture (SIC) helps predict prognosis in solid Tumors (T) but has been poorly investigated in gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs). We tested whether GEP-NENs profiling for adaptive immunity-related SIC markers, as well as inflammatory (COX2),EMT [Beta-catenin (B-cat)] and oncogenic pathway signaling (pS6) markers,could improve Ki67 and/or MO-based prediction of OS and DFS.
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author: Milione M
Authors: Milione M, Miceli R, Pellegrinelli A, Spaggiari P, Tagliabue G,
Keywords: Neuroendocrine, Ki-67, Morphology, Immune contexture, PDL1, Beta-Catenin,
Introduction: In pancreatic neuroendocrine neoplasms (pNENs), size ≤20 mm and Ki-67 ≤2% suggest indolent behavior, but no factor alone can predict prognosis.
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author: Milione M
Authors: Milione M, Maisonneuv P, Pellegrinelli A, Spaggiari P, Centonze G,
Keywords: Ki-67, Prognosis, Pancreas, Neuroendocrine, size, liver metastases, Biopsy, Surgical,
Introduction: Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are divided into different prognostic categories according to Ki67 class (≤2%: 2%-20%; 20%-55%; >55%); treatment strategies based on this classification are not fully effective.
Conference: 14th Annual ENETSConcerence (2017)
Presenting Author: Milione M
Authors: Milione M, Miceli R, Pellegrinelli A, Centonze G, Barretta F,
Keywords: Ki67, immune-related markers, disease-free survival, PD-L1,
#1753 Ki67 Is Able to Predict Pancreatic NENs Prognosis Irrespective of Their Size
Introduction: In pancreatic neuroendocrine neoplasms (pNENs), size <20mm and Ki67≤2% suggest indolent behavior. None of these factors alone predicts prognosis. No other predictive factors have been suggested.
Conference: 14th Annual ENETSConcerence (2017)
Presenting Author: Milione M
Authors: Milione M, Maisonneuve P, Pellegrinelli A, Centonze G, Coppa J,
Keywords: Ki67, PFS, pancreatic, NEN,